Systems analysis of the prostate transcriptome in African-American men compared with European-American men

• Published in: Pharmacogenomics Vol. 17; no. 10; pp. 1129 - 1143
• Main Authors: Hardiman, Gary, Savage, Stephen J, Hazard, E Starr, Wilson, Robert C, Courtney, Sean M, Smith, Michael T, Hollis, Bruce W, Halbert, Chanita Hughes, Gattoni-Celli, Sebastiano
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.07.2016
• Subjects: African Americans; African Americans - genetics; African-American; Aged; Biomarkers; Biopsy; Cholecalciferol - administration & dosage; Cohort Studies; Dietary Supplements; Disease prevention; European Continental Ancestry Group - genetics; Gene expression; Genomes; health disparities; Humans; Immune response; Inflammation; Male; Middle Aged; Prospective Studies; prostate; Prostate - drug effects; Prostate - physiology; Prostate - surgery; Prostate cancer; Prostatectomy; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - genetics; Prostatic Neoplasms - surgery; Racial differences; RNA-seq; Student athletes; Supplements; Surgery; Systems Analysis; transcription; Transcriptome - drug effects; Transcriptome - genetics; Vitamin D; Vitamin D3; Vitamin deficiency; United States > US; prostate; health disparities; RNA-seq; transcription; African–American; vitamin D
• ISSN: 1462-2416; 1744-8042
• DOI: 10.2217/pgs-2016-0025

African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D supplementation. Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery. AA show higher expression of genes associated with immune response and inflammation. Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D supplementation.