A New Biomarker Tool for Risk Stratification in " de novo " Acute Heart Failure (OROME)
Inflammation is one of the mechanisms involved in heart failure (HF) pathophysiology. Thus, the acute phase reactant protein, orosomucoid, was associated with a worse post-discharge prognosis in acute HF (AHF). However, the presence of anti-inflammatory adipokine, omentin, might protect and reduce t...
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Published in | Frontiers in physiology Vol. 12; p. 736245 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
13.01.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Inflammation is one of the mechanisms involved in heart failure (HF) pathophysiology. Thus, the acute phase reactant protein, orosomucoid, was associated with a worse post-discharge prognosis in
acute HF (AHF). However, the presence of anti-inflammatory adipokine, omentin, might protect and reduce the severity of the disease. We wanted to evaluate the value of omentin and orosomucoid combination for stratifying the risk of these patients.
Two independent cohorts of patients admitted for
AHF in two centers were included in the study (
= 218). Orosomucoid and omentin circulating levels were determined by ELISA at discharge. Patients were followed-up for 317 (3-575) days. A predictive model was determined for the primary endpoint, death, and/or HF readmission. Differences in survival were evaluated using a Log-rank test. According to cut-off values of orosomucoid and omentin, patients were classified as UpDown (high orosomucoid and low omentin levels), equal (both proteins high or low), and DownUp (low orosomucoid and high omentin levels). The Kaplan Meier determined a worse prognosis for the UpDown group (Long-rank test
= 0.02). The predictive model that includes the combination of orosomucoid and omentin groups (OROME) + NT-proBNP values achieved a higher C-index = 0.84 than the predictive model with NT-proBNP (C-index = 0.80) or OROME (C-index = 0.79) or orosomucoid alone (C-index = 0.80).
The orosomucoid and omentin determination stratifies
AHF patients into the high, mild, and low risk of rehospitalization and/or death for HF. Its combination with NT-proBNP improves its predictive value in this group of patients. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Clinical and Translational Physiology, a section of the journal Frontiers in Physiology These authors have contributed equally to this work Edited by: Michael Lichtenauer, Paracelsus Medical University, Austria Reviewed by: Juan Badimon, Icahn School of Medicine at Mount Sinai, United States; Nicola Riccardo Pugliese, University of Pisa, Italy; Carmine Savoia, Sapienza University of Rome, Italy; Gonzalo Barge Caballero, A Coruña University Hospital Complex (CHUAC), Spain; Rafael Vidal-Pérez, A Coruña University Hospital Complex (CHUAC), Spain; Alexander E. Berezin, Zaporizhia State Medical University, Ukraine |
ISSN: | 1664-042X 1664-042X |
DOI: | 10.3389/fphys.2021.736245 |