BDNF Gene's Role in Schizophrenia: From Risk Allele to Methylation Implications

• Published in: Frontiers in psychiatry Vol. 11; p. 564277
• Main Authors: Fu, Xiaoqian, Wang, Jun, Du, Jianbin, Sun, Jing, Baranova, Ancha, Zhang, Fuquan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.12.2020
• Subjects: BDNF; methylation; Psychiatry; rs6265; schizophrenia; single nucleotide polymorphism; rs6265; schizophrenia; BDNF; single nucleotide polymorphism; methylation

Background: Schizophrenia (SZ) is a severe chronic mental disorder with complex genetic mechanisms. Brain-derived neurotrophic factor (BDNF) is one of promising candidate genes for SZ, and rs6265 is a non-synonymous single nucleotide polymorphism (SNP) in BDNF. Methods: In this study, we performed a...