BDNF Gene's Role in Schizophrenia: From Risk Allele to Methylation Implications

Background: Schizophrenia (SZ) is a severe chronic mental disorder with complex genetic mechanisms. Brain-derived neurotrophic factor (BDNF) is one of promising candidate genes for SZ, and rs6265 is a non-synonymous single nucleotide polymorphism (SNP) in BDNF. Methods: In this study, we performed a...

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Published inFrontiers in psychiatry Vol. 11; p. 564277
Main Authors Fu, Xiaoqian, Wang, Jun, Du, Jianbin, Sun, Jing, Baranova, Ancha, Zhang, Fuquan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.12.2020
Subjects
BDNF
methylation
Psychiatry
rs6265
schizophrenia
single nucleotide polymorphism
rs6265
schizophrenia
BDNF
single nucleotide polymorphism
methylation
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Summary:Background: Schizophrenia (SZ) is a severe chronic mental disorder with complex genetic mechanisms. Brain-derived neurotrophic factor (BDNF) is one of promising candidate genes for SZ, and rs6265 is a non-synonymous single nucleotide polymorphism (SNP) in BDNF. Methods: In this study, we performed a case-control association study of rs6265 in a cohort of Han Chinese population from eastern China, including 1,407 SZ patients and 1,136 healthy controls; and carried out a cis-mQTL (Methylation Quantitative Trait Loci) analysis for BDNF rs6265. Results: We found a positive association of rs6265 with SZ ( P = 0.037), with the minor allele (A) of rs6265 conferring a protecting effect for SZ (OR = 0.89). Furthermore, cis-mQTL analysis indicates that rs6265 is associated with several methylation loci surrounding BDNF. Conclusions: Together, our findings provide further evidence to support the involvement of BDNF gene in the genesis of SZ.
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Reviewed by: Chunxia Yang, First Hospital of Shanxi Medical University, China; Sha Liu, Guangzhou Medical University, China
This article was submitted to Schizophrenia, a section of the journal Frontiers in Psychiatry
Edited by: Ingrid Melle, University of Oslo, Norway
ISSN:1664-0640
1664-0640
DOI:10.3389/fpsyt.2020.564277