Urinary MMP-9/UCr association with albumin concentration and albumin-creatinine-ratio in Mexican patients with type 2 diabetes mellitus

• Published in: PeerJ (San Francisco, CA) Vol. 8; p. e10474
• Main Authors: Arcos-Sacramento, Víctor Gildardo, Sampieri, Clara Luz, Sandoval-Lozano, Víctor Hugo, Orozco-Ortega, Rubén Arturo, Acuña-Hernández, Mariel Alejandra, Morales-Romero, Jaime, Hernández-Hernández, Magda Elena, Rodríguez-Hernández, Arturo
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 16.12.2020; PeerJ, Inc; PeerJ Inc
• Subjects: Albumin; Analysis; Antibiotics; Anuria; Biochemistry; Biomarkers; Cardiovascular diseases; Cell adhesion & migration; Chronic kidney failure; Creatinine; Diabetes; Diabetes and Endocrinology; Diabetes mellitus (non-insulin dependent); Enzyme-linked immunosorbent assay; Enzymes; Exercise; Extracellular matrix; Gelatinase B; Health aspects; Hematology; Hematuria; Kidney diseases; Liver cirrhosis; Matrix metalloproteinase; Medical research; Metalloproteinase; Morbidity; Mortality; Multivariate analysis; Nephrology; Patients; Peptides; Public Health; Rheumatoid arthritis; Sperm; Type 2 diabetes; Urine; Variables; Mexico; Diabetes mellitus; Chronic Kidney Disease; Matrix Metalloproteinases
• ISSN: 2167-8359; 2167-8359
• DOI: 10.7717/peerj.10474

Chronic kidney disease is one of the most common complications of type 2 diabetes mellitus (T2DM), causing an increased risk of cardiovascular morbidity and mortality. Matrix metalloproteinase (MMP) activity has been proposed as useful biomarker for diabetic renal and vascular complications. A cross-sectional study was conducted among T2DM patients who attended a public secondary hospital in Mexico. We performed clinical, biochemical, and microbiological assessments, as well chronic kidney disease diagnosis according to the KDIGO guideline. Urinary MMP-9 was quantified by ELISA and adjusted using urinary creatinine (UCr). A total of 111 patients were included. Most participants were women (66%). Mean age was 61 ± 10 years and median T2DM duration was estimated at 11 years. Through multivariate analysis, MMP-9/UCr was found to be associated with albumin concentration and albumin to creatinine ratio. Validation of non-invasive biomarkers of chronic kidney disease among T2DM patients is necessary. Here, we demonstrate MMP-9/UCr as a potential biomarker of albumin concentration and albumin to creatinine ratio in Mexican patients with T2DM.