Isolation rearing significantly perturbs brain metabolism in the thalamus and hippocampus

• Published in: Neuroscience Vol. 223; pp. 457 - 464
• Main Authors: Bonab, A.A, Fricchione, J.G, Gorantla, S, Vitalo, A.G, Auster, M.E, Levine, S.J, Scichilone, J.M, Hegde, M, Foote, W, Fricchione, G.L, Denninger, J.W, Yarmush, D.M, Fischman, A.J, Yarmush, M.L, Levine, J.B
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 25.10.2012; Elsevier
• Subjects: Animals; Animals, Newborn; Biological and medical sciences; biomarker; brain; Brain Mapping; childhood adversity; FDG; Fluorodeoxyglucose F18; Fundamental and applied biological sciences. Psychology; Hippocampus - diagnostic imaging; Hippocampus - metabolism; IEG; Image Processing, Computer-Assisted; isolation rearing; Magnetic Resonance Imaging; Male; Neurology; PET; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Social Isolation; stress; Thalamus - diagnostic imaging; Thalamus - metabolism; Vertebrates: nervous system and sense organs; post natal day; stress; flourodeoxyglucose; medial prefrontal cortex; group reared; isolation rearing; standard uptake value; FDG; GLM; IR; IEG; GR; brain; childhood adversity; biomarker; mPFC; isolation reared; SUV; general linear modeling; immediate early gene; positron emission tomography; PET; PN; Central nervous system; Biological marker; Metabolism; Stress; Encephalon; Thalamus; Hippocampus
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.07.032

Highlights ► Isolation-reared (IR) rats had decreased PET FDG uptake in the hippocampus and the thalamus. ► The decreased FDG uptake of IR rats in the hippocampus corresponded to decreased IEG expression in this region. ► PET FDG may serve as a translational biomarker of neurobiological factors in chronic psychosocial stress.