Multidimensional significance of crystallin protein–protein interactions and their implications in various human diseases

• Published in: Biochimica et biophysica acta Vol. 1860; no. 1; pp. 222 - 233
• Main Authors: Anbarasu, Kumarasamy, Sivakumar, Jeyarajan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2016
• Subjects: Binding Sites; biomarkers; Cardiomyopathies - metabolism; Cataract; Cataract - metabolism; Crystallin; crystallins; Crystallins - chemistry; Crystallins - metabolism; etiology; eye lens; functional properties; human diseases; Humans; metal ions; Mutation; Neoplasms - metabolism; Neurodegenerative Diseases - metabolism; pathogenesis; post-translational modification; Protein Binding; Protein Interaction Mapping; protein-protein interactions; Protein–protein interaction; refractive index; tissues; Cataract; Crystallin; Mutation; Protein–protein interaction
• ISSN: 0304-4165; 0006-3002; 1872-8006
• DOI: 10.1016/j.bbagen.2015.09.005

Crystallins are the important structural and functional proteins in the eye lens responsible for refractive index. Post-translational modifications (PTMs) and mutations are major causative factors that affect crystallin structural conformation and functional characteristics thus playing a vital role in the etiology of cataractogenesis. The significance of crystallin protein–protein interactions (PPIs) in the lens and non-lenticular tissues is summarized. Aberrancy of PPIs between crystallin, its associated protein and metal ions has been accomplished in various human diseases including cataract. A detailed account on multidimensional structural and functional significance of crystallin PPI in humans must be brought into limelight, in order to understand the biochemical and molecular basis augmenting the aberrancies of such interaction. In this scenario, the present review is focused to shed light on studies which will aid to expand our present understanding on disease pathogenesis related to loss of PPI thereby paving the way for putative future therapeutic targets to curb such diseases. The interactions with α-crystallins always aid to protect their structural and functional characteristics. The up-regulation of αB-crystallin in the non-lenticular tissues always decodes as biomarker for various stress related disorders. For better understanding and treatment of various diseases, PPI studies provide overall outline about the structural and functional characteristics of the proteins. This information not only helps to find out the route of cataractogenesis but also aid to identify potential molecules to inhibit/prevent the further development of such complicated phenomenon. This article is part of a Special Issue entitled Crystallin Biochemistry in Health and Disease. •Structural and functional significance of α-crystallin Protein-protein interaction (PPI) with lens associated proteins are narrated•Merits and demerits of PPI techniques are discussed•Significance of α-crystallin PPI with non-lenticular proteins are illustrated•Future scope of crystallin studies are specified