Beyond the basal ganglia: cFOS expression in the cerebellum in response to acute and chronic dopaminergic alterations

• Published in: Neuroscience Vol. 267; pp. 219 - 231
• Main Authors: Herrera-Meza, G, Aguirre-Manzo, L, Coria-Avila, G.A, Lopez-Meraz, M.L, Toledo-Cárdenas, R, Manzo, J, Garcia, L.I, Miquel, M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 16.05.2014; Elsevier
• Subjects: Analysis of Variance; Anesthetics, Local - pharmacology; Animals; Biological and medical sciences; cerebellum; Cerebellum - drug effects; Cerebellum - metabolism; dopamine; Dopamine - metabolism; Electromyography; Functional Laterality; Fundamental and applied biological sciences. Psychology; GABA Antagonists - pharmacology; haloperidol; Jaw; Lidocaine - pharmacology; Male; Medical sciences; Microinjections; Movement - drug effects; Neural Pathways - physiology; Neurology; Neuropharmacology; Pharmacology. Drug treatments; picrotoxin; Picrotoxin - pharmacology; Proto-Oncogene Proteins c-fos - metabolism; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Wistar; substantia nigra; Substantia Nigra - physiology; Tartrates - pharmacology; Vertebrates: nervous system and sense organs; substantia nigra; 6-OHDA; SNc; DN; STN; dentate nucleus; SN reticulata; cerebellum; substantia nigra pars compacta; haloperidol; 6-hydroxydopamine; PD; picrotoxin; SNr; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP; subtalamic nucleus; dopamine; Parkinson’s disease; PN; pontine nuclei; Cerebellum; Dopamine; Neuroleptic; Psychotropic; Acute; Central nervous system; Basal ganglion; Haloperidol; Catecholamine; Encephalon; Chronic; Locus niger; Neurotransmitter; Picrotoxin
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.02.046

Highlights • Acute stimulation of the SNc raises neuronal activity in the granular layer. • Stimulating SNc reduces neuronal activity in the fastigial nucleus. • Chronic haloperidol down-regulates neuronal activity in the granular layer. • Chronic dopaminergic antagonism enhances neuronal activity in the hemisphere. • DA manipulations modify activity in motor and non-motor cerebellar domains.