The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?

The incidence of allergic disorders has been increasing over the past few decades, especially in industrialized countries. Allergies can affect people of any age. The pathogenesis of allergic diseases is complex and involves genetic, epigenetic, and environmental factors, and the response to medicat...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in cellular and infection microbiology Vol. 11; p. 650893
Main Authors Han, Pei, Gu, Jian-Qing, Li, Li-Sha, Wang, Xue-Yan, Wang, Hong-Tian, Wang, Yan, Chang, Christopher, Sun, Jin-Lyu
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.04.2021
Subjects
advanced techniques
allergic disorders
Cellular and Infection Microbiology
Dysbiosis
Gastrointestinal Microbiome
gut microbiome
Humans
Hypersensitivity
interactions
Microbiota
therapeutic interventions
therapeutic interventions
advanced techniques
allergic disorders
gut microbiome
interactions
Online AccessGet full text

Cover

More Information
Summary:The incidence of allergic disorders has been increasing over the past few decades, especially in industrialized countries. Allergies can affect people of any age. The pathogenesis of allergic diseases is complex and involves genetic, epigenetic, and environmental factors, and the response to medication is very variable. For some patients, avoidance is the sole effective therapy, and only when the triggers are identifiable. In recent years, the intestinal microbiota has emerged as a significant contributor to the development of allergic diseases. However, the precise mechanisms related to the effects of the microbiome on the pathogenesis of allergic diseases are unknown. This review summarizes the recent association between allergic disorders and intestinal bacterial dysbiosis, describes the function of gut microbes in allergic disease development from both preclinical and clinical studies, discusses the factors that influence gut microbial diversity and advanced techniques used in microbial analysis. Ultimately, more studies are required to define the host-microbial relationship relevant to allergic disorders and amenable to new therapeutic interventions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Reviewed by: Cristiano Caruso, Catholic University of the Sacred Heart, Italy; Gabriele Rumi, Agostino Gemelli University Polyclinic, Italy; Eleonora Nucera, Catholic University of the Sacred Heart, Italy
These authors have contributed equally to this work
Edited by: Francesca Romana Ponziani, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Italy
This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2021.650893