Impact of Mediterranean diet on metabolic syndrome, cancer and longevity

Obesity symbolizes a major public health problem. Overweight and obesity are associated to the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose tissue is metabolically active and an endocrine organ, whose dysregulation causes a low-grade inflammatory state and ecto...

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Published inOncotarget Vol. 8; no. 5; pp. 8947 - 8979
Main Authors Di Daniele, Nicola, Noce, Annalisa, Vidiri, Maria Francesca, Moriconi, Eleonora, Marrone, Giulia, Annicchiarico-Petruzzelli, Margherita, D’Urso, Gabriele, Tesauro, Manfredi, Rovella, Valentina, De Lorenzo, Antonino
Format Journal Article
LanguageEnglish
Published United States Impact Journals LLC 31.01.2017
Subjects
Diet, Healthy
Diet, Mediterranean
Humans
Longevity
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Metabolic Syndrome - prevention & control
Neoplasms - diagnosis
Neoplasms - epidemiology
Neoplasms - prevention & control
Protective Factors
Review
Risk Assessment
Risk Factors
Risk Reduction Behavior
Time Factors
antioxidant
cancer
Mediterranean diet
obesity
public health
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Summary:Obesity symbolizes a major public health problem. Overweight and obesity are associated to the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose tissue is metabolically active and an endocrine organ, whose dysregulation causes a low-grade inflammatory state and ectopic fat depositions. The Mediterranean Diet represents a possible therapy for metabolic syndrome, preventing adiposopathy or "sick fat" formation.The Mediterranean Diet exerts protective effects in elderly subjects with and without baseline of chronic diseases. Recent studies have demonstrated a relationship between cancer and obesity. In the US, diet represents amount 30-35% of death causes related to cancer. Currently, the cancer is the second cause of death after cardiovascular diseases worldwide. Furthermore, populations living in the Mediterranean area have a decreased incidence of cancer compared with populations living in Northern Europe or the US, likely due to healthier dietary habits. The bioactive food components have a potential preventive action on cancer. The aims of this review are to evaluate the impact of Mediterranean Diet on onset, progression and regression of metabolic syndrome, cancer and on longevity.
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ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.13553