Mobile Carbapenemase Genes in Pseudomonas aeruginosa

Carbapenem-resistant is one of the major concerns in clinical settings impelling a great challenge to antimicrobial therapy for patients with infections caused by the pathogen. While membrane permeability, together with derepression of the intrinsic beta-lactamase gene, is the global prevailing mech...

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Published inFrontiers in microbiology Vol. 12; p. 614058
Main Authors Yoon, Eun-Jeong, Jeong, Seok Hoon
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 18.02.2021
Subjects
carbapenem resistance
carbapenemase
genomic islands
Microbiology
mobile genetic elements
molecular epidemiology
Pseudomonas aeruginosa
molecular epidemiology
Pseudomonas aeruginosa
mobile genetic elements
carbapenemase
carbapenem resistance
genomic islands
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Summary:Carbapenem-resistant is one of the major concerns in clinical settings impelling a great challenge to antimicrobial therapy for patients with infections caused by the pathogen. While membrane permeability, together with derepression of the intrinsic beta-lactamase gene, is the global prevailing mechanism of carbapenem resistance in , the acquired genes for carbapenemases need special attention because horizontal gene transfer through mobile genetic elements, such as integrons, transposons, plasmids, and integrative and conjugative elements, could accelerate the dissemination of the carbapenem-resistant . This review aimed to illustrate epidemiologically the carbapenem resistance in , including the resistance rates worldwide and the carbapenemase-encoding genes along with the mobile genetic elements responsible for the horizontal dissemination of the drug resistance determinants. Moreover, the modular mobile elements including the carbapenemase-encoding gene, also known as the resistance islands, are scrutinized mostly for their structures.
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Reviewed by: Vincenzo Di Pilato, University of Genoa, Italy; Bartolome Moya Canellas, Instituto de Investigación Sanitaria de Palma, Spain
Edited by: Spyros Pournaras, National and Kapodistrian University of Athens, Greece
This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2021.614058