Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy

The intestinal epithelial tract forms a dynamic lining of the digestive system consisting of a range of epithelial cell sub-types with diverse functions fulfilling specific niches. The intestinal epithelium is more than just a physical barrier regulating nutrient uptake, rather it plays a critical r...

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Published inFrontiers in immunology Vol. 11; p. 604054
Main Authors Ali, Ayesha, Tan, HuiYing, Kaiko, Gerard E
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 07.12.2020
Subjects
allergy
anaphyalaxis
epithelium
Immunology
intestinal immunity
microbiota
microbiota
allergy
anaphyalaxis
epithelium
intestinal immunity
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Summary:The intestinal epithelial tract forms a dynamic lining of the digestive system consisting of a range of epithelial cell sub-types with diverse functions fulfilling specific niches. The intestinal epithelium is more than just a physical barrier regulating nutrient uptake, rather it plays a critical role in homeostasis through its intrinsic innate immune function, pivotal regulation of antigen sensitization, and a bi-directional interplay with the microbiota that evolves with age. In this review we will discuss these functions of the epithelium in the context of food allergy.
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Reviewed by: Barbara Wróblewska, Institute of Animal Reproduction and Food Research (PAN), Poland; Kathryn A. Knoop, Mayo Clinic, United States
Edited by: Simon Patrick Hogan, University of Michigan, United States
These authors have contributed equally to this work
This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.604054