Modulation of Gut Microbiota to Enhance Effect of Checkpoint Inhibitor Immunotherapy

• Published in: Frontiers in immunology Vol. 12; p. 669150
• Main Authors: Wu, Jianmin, Wang, Shan, Zheng, Bo, Qiu, Xinyao, Wang, Hongyang, Chen, Lei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.06.2021
• Subjects: Adaptive Immunity; Animals; Bacteria - immunology; cancer treatment; CTLA-4; Dysbiosis; Fecal Microbiota Transplantation; Gastrointestinal Microbiome - immunology; Host-Pathogen Interactions; Humans; immune checkpoint inhibitor; Immune Checkpoint Inhibitors - therapeutic use; Immunity, Innate; Immunology; Immunotherapy; Neoplasms - diet therapy; Neoplasms - drug therapy; Neoplasms - immunology; Neoplasms - microbiology; PD-1; Probiotics - therapeutic use; Treatment Outcome; tumor; tumor immunotherapy; Tumor Microenvironment - immunology; cancer treatment; immune checkpoint inhibitor; CTLA-4; PD-1; tumor; tumor immunotherapy

Accumulating evidence demonstrated the crucial role of gut microbiota in many human diseases, including cancer. Checkpoint inhibitor therapy has emerged as a novel treatment and has been clinically accepted as a major therapeutic strategy for cancer. Gut microbiota is related to cancer and the effec...