Akt isoforms in the immune system

Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed in innate immune cells, it plays crucial roles i...

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Published inFrontiers in immunology Vol. 13; p. 990874
Main Authors Guerau-de-Arellano, Mireia, Piedra-Quintero, Zayda L, Tsichlis, Philip N
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 23.08.2022
Subjects
Akt
Akt1
Akt2
Akt3
Cell Differentiation
immune cells
Immune System - metabolism
Immunology
Protein Isoforms - metabolism
Proto-Oncogene Proteins c-akt - metabolism
Akt1
immune cells
Akt
Akt3
Akt2
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Abstract Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed in innate immune cells, it plays crucial roles in both innate and adaptive immune cell development and/or effector functions. In this review, we explore what's known about the role of Akt in innate and adaptive immune cells. Wherever possible, we discuss the overlapping and distinct role of the three Akt isoforms, namely Akt1, Akt2, and Akt3, in immune cells.
AbstractList Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt’s expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed in innate immune cells, it plays crucial roles in both innate and adaptive immune cell development and/or effector functions. In this review, we explore what’s known about the role of Akt in innate and adaptive immune cells. Wherever possible, we discuss the overlapping and distinct role of the three Akt isoforms, namely Akt1, Akt2, and Akt3, in immune cells.
Author Guerau-de-Arellano, Mireia
Tsichlis, Philip N
Piedra-Quintero, Zayda L
AuthorAffiliation 3 Department of Microbial Infection and Immunity, The Ohio State University , Columbus, OH , United States
1 School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University , Columbus, OH , United States
2 Institute for Behavioral Medicine Research, The Ohio State University , Columbus, OH , United States
4 Department of Neuroscience, The Ohio State University , Columbus, OH , United States
5 The Ohio State University Comprehensive Cancer Center, The Ohio State University , Columbus, OH , United States
6 Department of Cancer Biology and Genetics, The Ohio State University , Columbus, OH , United States
AuthorAffiliation_xml – name: 2 Institute for Behavioral Medicine Research, The Ohio State University , Columbus, OH , United States
– name: 1 School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University , Columbus, OH , United States
– name: 4 Department of Neuroscience, The Ohio State University , Columbus, OH , United States
– name: 5 The Ohio State University Comprehensive Cancer Center, The Ohio State University , Columbus, OH , United States
– name: 6 Department of Cancer Biology and Genetics, The Ohio State University , Columbus, OH , United States
– name: 3 Department of Microbial Infection and Immunity, The Ohio State University , Columbus, OH , United States
Author_xml – sequence: 1
  givenname: Mireia
  surname: Guerau-de-Arellano
  fullname: Guerau-de-Arellano, Mireia
  organization: The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States
– sequence: 2
  givenname: Zayda L
  surname: Piedra-Quintero
  fullname: Piedra-Quintero, Zayda L
  organization: School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, United States
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  givenname: Philip N
  surname: Tsichlis
  fullname: Tsichlis, Philip N
  organization: Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, United States
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Copyright Copyright © 2022 Guerau-de-Arellano, Piedra-Quintero and Tsichlis.
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Keywords Akt1
immune cells
Akt
Akt3
Akt2
Language English
License Copyright © 2022 Guerau-de-Arellano, Piedra-Quintero and Tsichlis.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Edited by: Françoise Meylan, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH), United States
Reviewed by: Wenjian Gan, Medical University of South Carolina, United States; Bin Zhao, National Clinical Research Center for Metabolic Diseases, Central South University, China
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Snippet Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's expression in most immune cells, either at baseline or upon...
Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt’s expression in most immune cells, either at baseline or upon...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 990874
SubjectTerms Akt
Akt1
Akt2
Akt3
Cell Differentiation
immune cells
Immune System - metabolism
Immunology
Protein Isoforms - metabolism
Proto-Oncogene Proteins c-akt - metabolism
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Title Akt isoforms in the immune system
URI https://www.ncbi.nlm.nih.gov/pubmed/36081513
https://search.proquest.com/docview/2712846200
https://pubmed.ncbi.nlm.nih.gov/PMC9445622
https://doaj.org/article/ed1c0cae6a8e4117bb2d5e49302d3186
Volume 13
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