Akt isoforms in the immune system

Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed in innate immune cells, it plays crucial roles i...

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Published inFrontiers in immunology Vol. 13; p. 990874
Main Authors Guerau-de-Arellano, Mireia, Piedra-Quintero, Zayda L, Tsichlis, Philip N
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 23.08.2022
Subjects
Akt
Akt1
Akt2
Akt3
Cell Differentiation
immune cells
Immune System - metabolism
Immunology
Protein Isoforms - metabolism
Proto-Oncogene Proteins c-akt - metabolism
Akt1
immune cells
Akt
Akt3
Akt2
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Summary:Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed in innate immune cells, it plays crucial roles in both innate and adaptive immune cell development and/or effector functions. In this review, we explore what's known about the role of Akt in innate and adaptive immune cells. Wherever possible, we discuss the overlapping and distinct role of the three Akt isoforms, namely Akt1, Akt2, and Akt3, in immune cells.
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This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Edited by: Françoise Meylan, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH), United States
Reviewed by: Wenjian Gan, Medical University of South Carolina, United States; Bin Zhao, National Clinical Research Center for Metabolic Diseases, Central South University, China
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.990874