Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver

• Published in: Biogerontology (Dordrecht) Vol. 9; no. 3; pp. 183 - 196
• Main Authors: Caro, Pilar, Gómez, José, López-Torres, Mónica, Sánchez, Inés, Naudí, Alba, Jove, Mariona, Pamplona, Reinald, Barja, Gustavo
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.06.2008; Springer; Springer Nature B.V
• Subjects: Aging; Animals; Apoptosis; Biological and medical sciences; Biomedical and Life Sciences; Carbohydrates; Cell Biology; Development. Metamorphosis. Moult. Ageing; Developmental Biology; Diet; DNA, Mitochondrial - metabolism; Free radicals; Fundamental and applied biological sciences. Psychology; Gas Chromatography-Mass Spectrometry; Geriatrics/Gerontology; Life Sciences; Lipids; Liver; Male; Methionine - administration & dosage; Mitochondria; Mitochondria, Liver - metabolism; Mitochondrial DNA; Oxidation; Oxidative Stress; Proteins; Rats; Rats, Wistar; Reactive Oxygen Species - metabolism; Research Article; Rodents; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Oxygen radicals; Mitochondria; Respiratory complexes; Aging; Longevity; Protein damage; Fatty acids; Caloric restriction; Oxidative stress; Fatty acids .Respiratory complexes; Thiol; Oxygen; Senescence; Rat; Digestive system; Liver; Ageing; Mitochondria .Caloric restriction; Rodentia; Methionine; Lipids; Protein; Sulfur containing aminoacid; Vertebrata; Generation; Mammalia

Dietary restriction (DR) lowers mitochondrial reactive oxygen species (ROS) generation and oxidative damage and increases maximum longevity in rodents. Protein restriction (PR) or methionine restriction (MetR), but not lipid or carbohydrate restriction, also cause those kinds of changes. However, pr...