Cytotoxic and antiprotozoal activity of flavonoids from Lonchocarpus spp

A number of flavonoids isolated from Lonchocarpus spp. were evaluated for their antiprotozoal and cytotoxic activity. Flavone 6 and chalcone 7 were found to be the most active against Leishmania parasites and against cell cultures of Leukemia P388DI and adenocarcinoma prostate PC-3.

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Bibliographic Details
Published inPhytomedicine (Stuttgart) Vol. 14; no. 7; pp. 530 - 533
Main Authors Borges-Argáez, R., Balnbury, L., Flowers, A., Giménez-Turba, A., Ruiz, G., Waterman, P.G., Peña-Rodríguez, L.M.
Format Journal Article
LanguageEnglish
Published Germany Elsevier GmbH 01.08.2007
Urban & Fischer Verlag
Subjects
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - toxicity
Antiprotozoal activity
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - pharmacology
Antiprotozoal Agents - toxicity
Beans
Bioflavonoids
Biological assay
Cell Cycle - drug effects
Cell Line, Tumor
Chalcone
Cytotoxic activity
Derris - chemistry
Flavone
Flavones
Flavones - chemistry
Flavones - pharmacology
Flavones - toxicity
Flavonoids
Humans
Legumes
Leukemia - pathology
Lonchocarpus
Male
Mimosaceae
Molecular Structure
Phytotherapy
Prostatic Neoplasms - pathology
United States
Flavonoids
Flavone
Chalcone
Antiprotozoal activity
Lonchocarpus
Cytotoxic activity
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Summary:A number of flavonoids isolated from Lonchocarpus spp. were evaluated for their antiprotozoal and cytotoxic activity. Flavone 6 and chalcone 7 were found to be the most active against Leishmania parasites and against cell cultures of Leukemia P388DI and adenocarcinoma prostate PC-3.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2006.11.027