Identification of Key microRNAs and Genes in Infantile Hemangiomas

Infantile hemangiomas (IHs) are the most frequent vascular tumors that occur during infancy. Microribonucleic acids (miRNAs) have been demonstrated as critical regulators of gene expression in various diseases. However, the function of miRNAs in IH still remains largely unknown. In the present study...

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Published inFrontiers in genetics Vol. 13; p. 766561
Main Authors Fu, Cong, Yang, Kun, Zou, Yuqing, Huo, Ran
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 11.03.2022
Subjects
angiogenesis
bioinformatics
Genetics
hub genes
infantile hemangiomas
micrornas
micrornas
infantile hemangiomas
hub genes
angiogenesis
bioinformatics
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Summary:Infantile hemangiomas (IHs) are the most frequent vascular tumors that occur during infancy. Microribonucleic acids (miRNAs) have been demonstrated as critical regulators of gene expression in various diseases. However, the function of miRNAs in IH still remains largely unknown. In the present study, we performed a miRNA microarray analysis of IH and identified 68 differentially expressed miRNAs (DEMs). In addition, miRNA-gene networks and protein-protein interactions were constructed, and the hub miRNAs and genes of IH were screened out. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were used for biological analysis of DEMs and differentially expressed genes (DEGs). The pathway enrichment analysis of DEMs revealed several tumor-related pathways, including proteoglycans in cancer, signaling pathway regulating pluripotency of stem cells and TGF-beta signaling pathway. DEGs were mainly enriched in biological processes, including intracellular signal transduction, cell adhesion, and cell death. KEGG pathway analysis indicated that DEGs were enriched in tumorigenesis- and angiogenesis-related pathways such as proteoglycans in cancer, MAPK signaling pathway and Rap1 signaling pathway. Collectively, this study first established a comprehensive miRNA-gene network in IH, which should provide novel insights into IH pathogenesis and be beneficial to the understanding of neovascularization-related disorders.
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This article was submitted to Computational Genomics, a section of the journal Frontiers in Genetics
Reviewed by: RuiJi Liu, Southeast University, China
Edited by: Juan Caballero, European Bioinformatics Institute (EMBL-EBI), United Kingdom
Loredana Le Pera, National Research Council (CNR), Italy
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2022.766561