Perioperative Levels of Glutathione Reductase in Liver Transplant Recipients with Hepatitis C Virus Cirrhosis

• Published in: Transplantation proceedings Vol. 44; no. 6; pp. 1542 - 1544
• Main Authors: Villegas, T, Olmedo, C, Muffak-Granero, K, Comino, A, Garrote, D, Bueno, P, Ferrón, J.-A
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 01.07.2012; Elsevier
• Subjects: Aged; Biological and medical sciences; Biomarkers - blood; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Glutathione Reductase - blood; Hepatitis C - blood; Hepatitis C - complications; Hepatitis C - enzymology; Human viral diseases; Humans; Infectious diseases; Liver Cirrhosis - blood; Liver Cirrhosis - enzymology; Liver Cirrhosis - surgery; Liver Cirrhosis - virology; Liver Transplantation; Male; Medical sciences; Middle Aged; Oxidative Stress; Preoperative Period; Reactive Oxygen Species - metabolism; Spain; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Time Factors; Tissue, organ and graft immunology; Treatment Outcome; Up-Regulation; Viral diseases; Viral hepatitis; Spain; Digestive system; Enzyme; Liver; Hepatic disease; Transplantation; Homotransplantation; Infection; Virus; Medicine; Cirrhosis; Perioperative; Treatment; Surgery; Viral disease; Digestive diseases; Graft; Oxidoreductases; Flaviviridae; Hepatitis C virus; Hepacivirus; Glutathione; Viral hepatitis C; Reductase
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2012.06.002

Abstract Surgical intervention causes oxidative stress leading to an adaptive responses by the body. To evaluate changes in the defense capacity of antioxidant enzymes, we determined the activity of glutathione reductase (GR) levels among liver transplant recipients with due to hepatitis C virus cirrhosis. The study was performed in 22 patients (16 males and 6 females) of average ages 52.63 ± 5.49 years for males and 59.67 ± 5.65 years for females. Blood samples for glutathione reductase activity were drawn on admission before as well as at 1, 6, and 12 h and 1, 2, 3, 5 and 7 days after the liver transplantation. Perioperative glutathione reductase levels were significant ( P = .014) over the period using Bonferroni tests. GR activity reached a maximum (15.6112 ± 6.56035 nmol/mg protein) at 3 days after liver transplantation (T3d) ( P = .001). The increased GR activity values detected perioperatively indicated scavenging of reactive oxygen species generated after liver transplantation of hepatitis C virus cirrhosis patients.