The first case of meningitis associated with SARS-CoV-2 BA.2 variant infection with persistent viremia

•Neurological disorders during COVID-19 are rare.•Plasmatic viremia could be persistent in patients who are immunocompromised.•Immunosuppression and blood-brain barrier injury could facilitate SARS-CoV-2 entry.•Central nervous system SARS-CoV-2 detection should be performed in neurological patients....

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Published inInternational journal of infectious diseases Vol. 124; pp. 38 - 40
Main Authors D'Abramo, Alessandra, Vita, Serena, Colavita, Francesca, Cimini, Eleonora, Haggiag, Shalom, Maffongelli, Gaetano, Valli, Maria Beatrice, Bevilacqua, Nazario, Corpolongo, Angela, Giancola, Maria Letizia, Maggi, Fabrizio, Agrati, Chiara, Nicastri, Emanuele
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.11.2022
Published by Elsevier Ltd on behalf of International Society for Infectious Diseases
Elsevier
Subjects
Blood barrier damage
Case Report
COVID-19
Meningitis
Omicron
COVID-19
Meningitis
Omicron
Blood barrier damage
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Summary:•Neurological disorders during COVID-19 are rare.•Plasmatic viremia could be persistent in patients who are immunocompromised.•Immunosuppression and blood-brain barrier injury could facilitate SARS-CoV-2 entry.•Central nervous system SARS-CoV-2 detection should be performed in neurological patients. Severe neurological disorders and vascular events during COVID-19 have been described. Here, we describe the first case of a female patient infected with the SARS-CoV-2 BA.2 Omicron variant of concern with meningitis with newly diagnosed central demyelinating disease.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2022.09.011