Reactive Oxygen Species in Pathogen Clearance: The Killing Mechanisms, the Adaption Response, and the Side Effects

Reactive oxygen species (ROS) are attractive weapons in both antibiotic-mediated killing and host-mediated killing. However, the involvement of ROS in antibiotic-mediated killing and complexities in host environments challenge the paradigm. In the case of bacterial pathogens, the examples of some ce...

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Published inFrontiers in microbiology Vol. 11; p. 622534
Main Authors Li, Hao, Zhou, Xuedong, Huang, Yuyao, Liao, Binyou, Cheng, Lei, Ren, Biao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 04.02.2021
Subjects
antibiotic resistance
antibiotic tolerance
metabolism remodeling
Microbiology
reactive oxygen species
secondary damage
virulence
antibiotic tolerance
secondary damage
metabolism remodeling
virulence
antibiotic resistance
reactive oxygen species
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Summary:Reactive oxygen species (ROS) are attractive weapons in both antibiotic-mediated killing and host-mediated killing. However, the involvement of ROS in antibiotic-mediated killing and complexities in host environments challenge the paradigm. In the case of bacterial pathogens, the examples of some certain pathogens thriving under ROS conditions prompt us to focus on the adaption mechanism that pathogens evolve to cope with ROS. Based on these, we here summarized the mechanisms of ROS-mediated killing of either antibiotics or the host, the examples of bacterial adaption that successful pathogens evolved to defend or thrive under ROS conditions, and the potential side effects of ROS in pathogen clearance. A brief section for new antibacterial strategies centered around ROS was also addressed.
Bibliography:ObjectType-Article-2
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Reviewed by: Tim Maisch, University of Regensburg, Germany; Kristin M. Burkholder, University of New England, United States
Edited by: Kirkwood M. Land, University of the Pacific, United States
This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2020.622534