Promising Advances in LINC01116 Related to Cancer

Long non-coding RNAs (lncRNAs) are RNAs with a length of no less than 200 nucleotides that are not translated into proteins. Accumulating evidence indicates that lncRNAs are pivotal regulators of biological processes in several diseases, particularly in several malignant tumors. Long intergenic non-...

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Published inFrontiers in cell and developmental biology Vol. 9; p. 736927
Main Authors Xu, Yating, Yu, Xiao, Zhang, Menggang, Zheng, Qingyuan, Sun, Zongzong, He, Yuting, Guo, Wenzhi
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 14.10.2021
Subjects
Cell and Developmental Biology
chemoresistance
human cancers
LINC01116
long non-coding RNA
prognosis
human cancers
chemoresistance
long non-coding RNA
prognosis
LINC01116
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Summary:Long non-coding RNAs (lncRNAs) are RNAs with a length of no less than 200 nucleotides that are not translated into proteins. Accumulating evidence indicates that lncRNAs are pivotal regulators of biological processes in several diseases, particularly in several malignant tumors. Long intergenic non-protein coding RNA 1116 (LINC01116) is a lncRNA, whose aberrant expression is correlated with a variety of cancers, including lung cancer, gastric cancer, colorectal cancer, glioma, and osteosarcoma. LINC01116 plays a crucial role in facilitating cell proliferation, invasion, migration, and apoptosis. In addition, numerous studies have recently suggested that LINC01116 has emerged as a novel biomarker for prognosis and therapy in malignant tumors. Consequently, we summarize the clinical significance of LINC01116 associated with biological processes in various tumors and provide a hopeful orientation to guide clinical treatment of various cancers in future studies.
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Edited by: Shiv K. Gupta, Mayo Clinic, United States
These authors have contributed equally to this work
Reviewed by: Luciana N. S. Andrade, Universidade de São Paulo, Brazil; Juliano Andreoli Miyake, Federal University of Santa Catarina, Brazil
This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.736927