Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration

The incidence of musculoskeletal diseases is steadily increasing with aging of the population. In the past years, extracellular vesicles (EVs) have gained attention in musculoskeletal research. EVs have been associated with various musculoskeletal pathologies as well as suggested as treatment option...

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Published inFrontiers in bioengineering and biotechnology Vol. 8; p. 624096
Main Authors Herrmann, Marietta, Diederichs, Solvig, Melnik, Svitlana, Riegger, Jana, Trivanović, Drenka, Li, Shushan, Jenei-Lanzl, Zsuzsa, Brenner, Rolf E, Huber-Lang, Markus, Zaucke, Frank, Schildberg, Frank A, Grässel, Susanne
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 20.01.2021
Subjects
Bioengineering and Biotechnology
cell-free therapeutics
exosomes
extracellular vesicles
iMP
MSC
musculoskeletal diseases
extracellular vesicles
MSC
iMP
exosomes
musculoskeletal diseases
cell-free therapeutics
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Abstract The incidence of musculoskeletal diseases is steadily increasing with aging of the population. In the past years, extracellular vesicles (EVs) have gained attention in musculoskeletal research. EVs have been associated with various musculoskeletal pathologies as well as suggested as treatment option. EVs play a pivotal role in communication between cells and their environment. Thereby, the EV cargo is highly dependent on their cellular origin. In this review, we summarize putative mechanisms by which EVs can contribute to musculoskeletal tissue homeostasis, regeneration and disease, in particular matrix remodeling and mineralization, pro-angiogenic effects and immunomodulatory activities. Mesenchymal stromal cells (MSCs) present the most frequently used cell source for EV generation for musculoskeletal applications, and herein we discuss how the MSC phenotype can influence the cargo and thus the regenerative potential of EVs. Induced pluripotent stem cell-derived mesenchymal progenitor cells (iMPs) may overcome current limitations of MSCs, and iMP-derived EVs are discussed as an alternative strategy. In the last part of the article, we focus on therapeutic applications of EVs and discuss both practical considerations for EV production and the current state of EV-based therapies.
AbstractList The incidence of musculoskeletal diseases is steadily increasing with aging of the population. In the past years, extracellular vesicles (EVs) have gained attention in musculoskeletal research. EVs have been associated with various musculoskeletal pathologies as well as suggested as treatment option. EVs play a pivotal role in communication between cells and their environment. Thereby, the EV cargo is highly dependent on their cellular origin. In this review, we summarize putative mechanisms by which EVs can contribute to musculoskeletal tissue homeostasis, regeneration and disease, in particular matrix remodeling and mineralization, pro-angiogenic effects and immunomodulatory activities. Mesenchymal stromal cells (MSCs) present the most frequently used cell source for EV generation for musculoskeletal applications, and herein we discuss how the MSC phenotype can influence the cargo and thus the regenerative potential of EVs. Induced pluripotent stem cell-derived mesenchymal progenitor cells (iMPs) may overcome current limitations of MSCs, and iMP-derived EVs are discussed as an alternative strategy. In the last part of the article, we focus on therapeutic applications of EVs and discuss both practical considerations for EV production and the current state of EV-based therapies.
Author Li, Shushan
Jenei-Lanzl, Zsuzsa
Herrmann, Marietta
Melnik, Svitlana
Riegger, Jana
Zaucke, Frank
Trivanović, Drenka
Brenner, Rolf E
Grässel, Susanne
Schildberg, Frank A
Diederichs, Solvig
Huber-Lang, Markus
AuthorAffiliation 5 Department of Orthopedic Surgery, Experimental Orthopedics, Centre for Medical Biotechnology (ZMB), University of Regensburg , Regensburg , Germany
7 Institute of Clinical and Experimental Trauma-Immunology, University Hospital of Ulm , Ulm , Germany
3 Research Centre for Experimental Orthopaedics, Centre for Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital , Heidelberg , Germany
8 Clinic for Orthopedics and Trauma Surgery, University Hospital Bonn , Bonn , Germany
4 Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm , Ulm , Germany
6 Dr. Rolf M. Schwiete Research Unit for Osteoarthritis, Orthopedic University Hospital Friedrichsheim , Frankfurt , Germany
2 Bernhard-Heine-Centrum for Locomotion Research, University of Würzburg , Würzburg , Germany
1 Interdisciplinary Center for Clinical Research (IZKF) Group Tissue Regeneration in Musculoskeletal Diseases, University Hospital Würzburg , Würzburg , Ge
AuthorAffiliation_xml – name: 5 Department of Orthopedic Surgery, Experimental Orthopedics, Centre for Medical Biotechnology (ZMB), University of Regensburg , Regensburg , Germany
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  surname: Schildberg
  fullname: Schildberg, Frank A
  organization: Clinic for Orthopedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany
– sequence: 12
  givenname: Susanne
  surname: Grässel
  fullname: Grässel, Susanne
  organization: Department of Orthopedic Surgery, Experimental Orthopedics, Centre for Medical Biotechnology (ZMB), University of Regensburg, Regensburg, Germany
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Copyright Copyright © 2021 Herrmann, Diederichs, Melnik, Riegger, Trivanović, Li, Jenei-Lanzl, Brenner, Huber-Lang, Zaucke, Schildberg and Grässel.
Copyright © 2021 Herrmann, Diederichs, Melnik, Riegger, Trivanović, Li, Jenei-Lanzl, Brenner, Huber-Lang, Zaucke, Schildberg and Grässel. 2021 Herrmann, Diederichs, Melnik, Riegger, Trivanović, Li, Jenei-Lanzl, Brenner, Huber-Lang, Zaucke, Schildberg and Grässel
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– notice: Copyright © 2021 Herrmann, Diederichs, Melnik, Riegger, Trivanović, Li, Jenei-Lanzl, Brenner, Huber-Lang, Zaucke, Schildberg and Grässel. 2021 Herrmann, Diederichs, Melnik, Riegger, Trivanović, Li, Jenei-Lanzl, Brenner, Huber-Lang, Zaucke, Schildberg and Grässel
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Keywords extracellular vesicles
MSC
iMP
exosomes
musculoskeletal diseases
cell-free therapeutics
Language English
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Reviewed by: Wei Seong Toh, National University of Singapore, Singapore; Santiago Roura, Germans Trias i Pujol Health Science Research Institute (IGTP), Spain
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This article was submitted to Preclinical Cell and Gene Therapy, a section of the journal Frontiers in Bioengineering and Biotechnology
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PublicationTitle Frontiers in bioengineering and biotechnology
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Snippet The incidence of musculoskeletal diseases is steadily increasing with aging of the population. In the past years, extracellular vesicles (EVs) have gained...
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SubjectTerms Bioengineering and Biotechnology
cell-free therapeutics
exosomes
extracellular vesicles
iMP
MSC
musculoskeletal diseases
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Title Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration
URI https://www.ncbi.nlm.nih.gov/pubmed/33553127
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