Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota

It was recently shown that the gut microbiota of both depression patients and depression model animals is significantly altered, suggesting that gut microbes are closely related to depression. Here, we investigated the effects of L.-derived alkaloids on the gut microbiota of mice with depression-lik...

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Published inFrontiers in cellular and infection microbiology Vol. 11; p. 665159
Main Authors Zhang, Ming, Li, Aoqiang, Yang, Qifang, Li, Jingyi, Wang, Lihua, Liu, Xiuxian, Huang, Yanxin, Liu, Lei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.04.2021
Subjects
Alkaloids
Animals
Cellular and Infection Microbiology
CUMS
Depression
function prediction
Gastrointestinal Microbiome
gut microbiota
Humans
Mice
RNA, Ribosomal, 16S
Sophora
Sophora alopecuroides L
Sophora alopecuroides L
depression
function prediction
gut microbiota
CUMS
alkaloids
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Summary:It was recently shown that the gut microbiota of both depression patients and depression model animals is significantly altered, suggesting that gut microbes are closely related to depression. Here, we investigated the effects of L.-derived alkaloids on the gut microbiota of mice with depression-like behaviors. We first established a mouse model of depression chronic unpredictable mild stress (CUMS) and detected changes in depression-like behaviors and depression-related indicators. Simultaneously, 16S rRNA sequencing was performed to investigate gut microbiota changes. L.-derived alkaloids improved depression-like behaviors and depression-related indicators in mice. The alkaloids decreased the gut microbiota diversity of CUMS mice and depleted intestinal differentially abundant "harmful" microbiota genera. Spearman analysis showed that there is a certain correlation between the differential microbiota ( , , , , , ), depression-like behaviors, and depression-related indicators. Combined with the predictive analysis of gut microbiota function, these results indicate that alkaloids improve depression in mice through modulating gut microbiota.
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Edited by: Zongxin Ling, Zhejiang University, China
This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology
Reviewed by: Zhendong Cai, Ningbo University, China; Palok Aich, National Institute of Science Education and Research (NISER), India; Jane Adair Mullaney, AgResearch Ltd, New Zealand
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2021.665159