Time-gated scintillator imaging for real-time optical surface dosimetry in total skin electron therapy

• Published in: Physics in medicine & biology Vol. 63; no. 9; p. 095009
• Main Authors: Bruza, Petr, Gollub, Sarah L, Andreozzi, Jacqueline M, Tendler, Irwin I, Williams, Benjamin B, Jarvis, Lesley A, Gladstone, David J, Pogue, Brian W
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 02.05.2018
• Subjects: Cherenkov radiation; Electrons - therapeutic use; Humans; intensified camera; radiotherapy; Scintillation Counting - instrumentation; scintillator; Skin Neoplasms - pathology; Skin Neoplasms - radiotherapy; surface dosimetry; Time Factors; total skin electron therapy
• ISSN: 0031-9155; 1361-6560; 1361-6560
• DOI: 10.1088/1361-6560/aaba19

The purpose of this study was to measure surface dose by remote time-gated imaging of plastic scintillators. A novel technique for time-gated, intensified camera imaging of scintillator emission was demonstrated, and key parameters influencing the signal were analyzed, including distance, angle and thickness. A set of scintillator samples was calibrated by using thermo-luminescence detector response as reference. Examples of use in total skin electron therapy are described. The data showed excellent room light rejection (signal-to-noise ratio of scintillation SNR     470), ideal scintillation dose response linearity, and 2% dose rate error. Individual sample scintillation response varied by 7% due to sample preparation. Inverse square distance dependence correction and lens throughput error (8% per meter) correction were needed. At scintillator-to-source angle and observation angle  <50°, the radiant energy fluence error was smaller than 1%. The achieved standard error of the scintillator cumulative dose measurement compared to the TLD dose was 5%. The results from this proof-of-concept study documented the first use of small scintillator targets for remote surface dosimetry in ambient room lighting. The measured dose accuracy renders our method to be comparable to thermo-luminescent detector dosimetry, with the ultimate realization of accuracy likely to be better than shown here. Once optimized, this approach to remote dosimetry may substantially reduce the time and effort required for surface dosimetry.