A case of COVID-19-associated rhino-orbito-cerebral mucormycosis caused by Apophysomyces variabilis with a review of the literature

A fatal case of COVID-19-associated mucormycosis (CAM) affected a 40-year-old woman who was initially admitted to our hospital due to a SARS-CoV-2 infection. Her clinical condition worsened, and she finally died because of respiratory failure, hemodynamic instability, and mucormycosis with invasion...

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Published inFrontiers in cellular and infection microbiology Vol. 12; p. 898477
Main Authors Erami, Mahzad, Mirhendi, Hossein, Momen-Heravi, Mansooreh, Hezaveh, Seyed Jamal Hashemi, Ahsaniarani, Amir Hossein, Sabet, Seddighe Sadat, Aboutalebian, Shima
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 14.10.2022
Subjects
Adult
Antifungal Agents - therapeutic use
antifungal susceptibility testing
apophysomyces variabilis
Cellular and Infection Microbiology
COVID-19
COVID-19 - complications
Female
Humans
immunocompetent patient
invasive fungal infection
Mucorales - genetics
mucormycosis
Mucormycosis - complications
Mucormycosis - diagnosis
Mucormycosis - drug therapy
SARS-CoV-2
COVID-19
invasive fungal infection
apophysomyces variabilis
immunocompetent patient
antifungal susceptibility testing
mucormycosis
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Summary:A fatal case of COVID-19-associated mucormycosis (CAM) affected a 40-year-old woman who was initially admitted to our hospital due to a SARS-CoV-2 infection. Her clinical condition worsened, and she finally died because of respiratory failure, hemodynamic instability, and mucormycosis with invasion into the orbit and probably the brain. According to DNA sequence analysis of the fungus isolated from the patient, was involved. This is the first published case of CAM and the third case of mucormycosis due to this mold.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Review-3
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ObjectType-Feature-5
ObjectType-Article-4
ObjectType-Report-1
Edited by: Thuy Le, Duke University, United States
Reviewed by: Fatemeh Ahangarkani, Mazandaran University of Medical Sciences, Sari, Iran; Eman A. Gouda M. Youssef, Lundquist Institute for Biomedical Innovation, United States
This article was submitted to Fungal Pathogenesis, a section of the journal Frontiers in Cellular and Infection Microbiology
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.898477