An Updated Review of Genetic Associations With Severe Adverse Drug Reactions: Translation and Implementation of Pharmacogenomic Testing in Clinical Practice

• Published in: Frontiers in pharmacology Vol. 13; p. 886377
• Main Authors: Wang, Chuang-Wei, Preclaro, Ivan Arni C., Lin, Wei-Hsiang, Chung, Wen-Hung
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.04.2022
• Subjects: adverse drug reactions; CYP; drug transporter; drug-induced liver injury; human leukocyte antigens; Pharmacology; stevens-johnson syndrome; drug-induced liver injury; adverse drug reactions; stevens-johnson syndrome; human leukocyte antigens; CYP; drug transporter; toxic epidermal necrolysis

Adverse drug reactions (ADR) remain the major problems in healthcare. Most severe ADR are unpredictable, dose-independent and termed as type B idiosyncratic reactions. Recent pharmacogenomic studies have demonstrated the strong associations between severe ADR and genetic markers, including specific...