Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects

1 H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second...

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Published inFrontiers in molecular biosciences Vol. 9; p. 839809
Main Authors Ghini, Veronica, Maggi, Laura, Mazzoni, Alessio, Spinicci, Michele, Zammarchi, Lorenzo, Bartoloni, Alessandro, Annunziato, Francesco, Turano, Paola
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 05.04.2022
Subjects
lipoproteins
metabolomics
Molecular Biosciences
NMR
SARS-CoV-2
vaccine
NMR
SARS-CoV-2
vaccine
metabolomics
lipoproteins
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Abstract 1 H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition.
AbstractList 1H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition.1H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition.
1 H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition.
H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition.
1H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition.
Author Zammarchi, Lorenzo
Bartoloni, Alessandro
Annunziato, Francesco
Maggi, Laura
Ghini, Veronica
Turano, Paola
Mazzoni, Alessio
Spinicci, Michele
AuthorAffiliation 6 Flow Cytometry Diagnostic Center and Immunotherapy , Careggi University Hospital , Florence , Italy
4 Department of Experimental and Clinical Medicine , University of Florence , Florence , Italy
1 Department of Chemistry , University of Florence , Florence , Italy
5 Infectious and Tropical Disease Unit , Careggi University Hospital , Florence , Italy
3 Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP) , Florence , Italy
2 Magnetic Resonance Center (CERM) , University of Florence , Florence , Italy
AuthorAffiliation_xml – name: 4 Department of Experimental and Clinical Medicine , University of Florence , Florence , Italy
– name: 1 Department of Chemistry , University of Florence , Florence , Italy
– name: 3 Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP) , Florence , Italy
– name: 5 Infectious and Tropical Disease Unit , Careggi University Hospital , Florence , Italy
– name: 2 Magnetic Resonance Center (CERM) , University of Florence , Florence , Italy
– name: 6 Flow Cytometry Diagnostic Center and Immunotherapy , Careggi University Hospital , Florence , Italy
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Keywords NMR
SARS-CoV-2
vaccine
metabolomics
lipoproteins
Language English
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Reviewed by: Chi-Fon Chang, Genomics Research Center, Academia Sinica, Taiwan
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This article was submitted to Metabolomics, a section of the journal Frontiers in Molecular Biosciences
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Snippet 1 H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10...
H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10...
1H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10...
1H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10...
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SubjectTerms lipoproteins
metabolomics
Molecular Biosciences
NMR
SARS-CoV-2
vaccine
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Title Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects
URI https://www.ncbi.nlm.nih.gov/pubmed/35480886
https://www.proquest.com/docview/2656747237
https://pubmed.ncbi.nlm.nih.gov/PMC9037139
https://doaj.org/article/45750eecf21141039b27e2162cd804ec
Volume 9
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