Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects

1 H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in molecular biosciences Vol. 9; p. 839809
Main Authors Ghini, Veronica, Maggi, Laura, Mazzoni, Alessio, Spinicci, Michele, Zammarchi, Lorenzo, Bartoloni, Alessandro, Annunziato, Francesco, Turano, Paola
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 05.04.2022
Subjects
lipoproteins
metabolomics
Molecular Biosciences
NMR
SARS-CoV-2
vaccine
NMR
SARS-CoV-2
vaccine
metabolomics
lipoproteins
Online AccessGet full text

Cover

More Information
Summary:1 H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Edited by: Wolfram Weckwerth, University of Vienna, Austria
Reviewed by: Chi-Fon Chang, Genomics Research Center, Academia Sinica, Taiwan
Sofia Moco, VU Amsterdam, Netherlands
This article was submitted to Metabolomics, a section of the journal Frontiers in Molecular Biosciences
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2022.839809