Infections With Enterohepatic Non- H. pylori Helicobacter Species in X-Linked Agammaglobulinemia: Clinical Cases and Review of the Literature

• Published in: Frontiers in cellular and infection microbiology Vol. 11; p. 807136
• Main Authors: Romo-Gonzalez, Carolina, Bustamante-Ogando, Juan Carlos, Yamazaki-Nakashimada, Marco Antonio, Aviles-Jimenez, Francisco, Otero-Mendoza, Francisco, Espinosa-Rosales, Francisco Javier, Espinosa-Padilla, Sara Elva, Scheffler Mendoza, Selma Cecilia, Durán-McKinster, Carola, García-Romero, Maria Teresa, Saez-de-Ocariz, Marimar, Lopez-Herrera, Gabriela
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.02.2022
• Subjects: Agammaglobulinemia - complications; Cellular and Infection Microbiology; cellulitis; Genetic Diseases, X-Linked - complications; H. bilis; H. cinaedi; Helicobacter - genetics; Helicobacter Infections - microbiology; Helicobacter pylori; Humans; non-H. pylori Helicobacters; pyoderma gangrenosum-like; X-linked Agammaglobulinemia; H. bilis; non-H. pylori Helicobacters; recurrent infections; pyoderma gangrenosum-like; H. cinaedi; cellulitis; X-linked Agammaglobulinemia
• ISSN: 2235-2988; 2235-2988
• DOI: 10.3389/fcimb.2021.807136

The genus is classified into two main groups according to its habitat: gastric and enterohepatic. Patients with X-linked agammaglobulinemia (XLA) appear to be associated with invasive infection with enterohepatic non-Helicobacter pylori species (NHPH), mainly and . Such infections are difficult to control and have a high potential for recurrence. The spectrum of illnesses caused by these species includes recurrent fever, bacteremia, arthritis, osteomyelitis, cellulitis, abdominal abscesses, and pyoderma gangrenosum-like ulcer. The presence of these is particularly difficult to diagnose and eradicate, as they are very fastidious bacteria and present resistance to several types of antibiotics. We report two clinical cases of XLA patients infected with H. These infections were chronic in these patients and could not be eradicated in one of them. We also review the cases of enterohepatic non- species (NHPH) in patients with this inborn error of immunity.