Natural Products from Medicinal Plants with Anti-Human Coronavirus Activities

Since the emergence of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) first reported in Wuhan, China in December 2019, COVID-19 has spread to all the continents at an unprecedented pace. This pandemic has caused not only hundreds of thousands of mortalities but also a huge ec...

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Published inMolecules (Basel, Switzerland) Vol. 26; no. 6; p. 1754
Main Authors Hafez Ghoran, Salar, El-Shazly, Mohamed, Sekeroglu, Nazim, Kijjoa, Anake
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 21.03.2021
MDPI AG
Subjects
ACE2
Animals
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Biological Products - chemistry
Biological Products - pharmacology
Biological Products - therapeutic use
COVID-19
enzyme inhibitors
Humans
medicinal plants
phytochemicals
Plants, Medicinal - chemistry
Review
SARS Virus - drug effects
SARS Virus - metabolism
SARS-CoV
Secondary Metabolism
Severe Acute Respiratory Syndrome - drug therapy
COVID-19
ACE2
phytochemicals
enzyme inhibitors
medicinal plants
SARS-CoV
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Summary:Since the emergence of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) first reported in Wuhan, China in December 2019, COVID-19 has spread to all the continents at an unprecedented pace. This pandemic has caused not only hundreds of thousands of mortalities but also a huge economic setback throughout the world. Therefore, the scientific communities around the world have focused on finding antiviral therapeutic agents to either fight or halt the spread of SARS-CoV-2. Since certain medicinal plants and herbal formulae have proved to be effective in treatment of similar viral infections such as those caused by SARS and Ebola, scientists have paid more attention to natural products for effective treatment of this devastating pandemic. This review summarizes studies and ethnobotanical information on plants and their constituents used for treatment of infections caused by viruses related to the coronavirus family. Herein, we provide a critical analysis of previous reports and how to exploit published data for the discovery of novel therapeutic leads to fight against COVID-19.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26061754