Prevalence of Human Papillomavirus Among Chinese Han and Mongols Minority Women in Inner Mongolia, China: Reflected by Self-Collected Samples in CHIMUST

• Published in: Frontiers in public health Vol. 10; p. 840879
• Main Authors: Guo, Chunlei, Du, Hui, Qu, Xinfeng, Duan, Xianzhi, Li, Jingran, Li, Ruizhen, Jin, Hua, Wang, Chun, Zhao, Chao, Bao, Juncui, Luo, Hongxue, Wei, Lihui, Belinson, J L, Wu, Ruifang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.05.2022
• Subjects: Alphapapillomavirus; cervical intraepithelial neoplasia; Cervical Intraepithelial Neoplasia - pathology; Cervical Intraepithelial Neoplasia - prevention & control; China - epidemiology; Chinese Han; distribution; Early Detection of Cancer; Female; human papillomavirus; Human papillomavirus 16 - genetics; Humans; Mongols minority; Papillomaviridae - genetics; Papillomavirus Infections - epidemiology; Papillomavirus Infections - genetics; Prevalence; Public Health; type-specific prevalence; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - prevention & control; China; distribution; type-specific prevalence; cervical intraepithelial neoplasia; Chinese Han; Mongols minority; human papillomavirus
• ISSN: 2296-2565; 2296-2565
• DOI: 10.3389/fpubh.2022.840879

The disparities of hr-HPV infection among races/ethnicities have not been fully discussed. This study aimed to investigate the difference of hr-HPV infection between Chinese Han and Mongols minority women in Inner Mongolia. Genotyping and histopathology data of Chinese Han and Mongols minority women in Inner Mongolia from Chinese Multi-Center Screening Trial were used to analyze the hr-HPV prevalence, and type-specific distribution in abnormal pathology results. The hr-HPV infection rates of Han women was 15.9% while of Mongols was 21.6% ( < 0.001). The most prevalent genotypes in Han women were ranked as HPV-16,-52,-18/-58,-31/-39, and-59 while in Mongols were-16,-31,-58,-18 and-52. When analyzing the age-specific of hr-HPV infection, two peaks were found at age of 40-44 (20.5%) and 55-59 (23.5%) years in Han women while three peaks were observed at age of 30-34 (22.1%), 45-49 (22.9%), and 55-59 (31.8%) years, respectively, in Mongols. HPV-16 accounting for 62.5 and 53.8% of the CINII+ in Han and Mongols, respectively. The prevalence of hr-HPV was significantly different between the Han and Mongols minority women in Inner Mongolia, races/ethnicities background should be taken into consideration for the refinement of cervical cancer screening strategies and vaccine implementation in China.