Global Perspectives on Immunization Against SARS-CoV-2 During Pregnancy and Priorities for Future Research: An International Consensus Paper From the World Association of Infectious Diseases and Immunological Disorders

• Published in: Frontiers in immunology Vol. 12; p. 808064
• Main Authors: Abu-Raya, Bahaa, Madhi, Shabir A, Omer, Saad B, Amirthalingam, Gayatri, Giles, Michelle L, Flanagan, Katie L, Zimmermann, Petra, O'Ryan, Miguel, Safadi, Marco A, Papaevangelou, Vassiliki, Maertens, Kirsten, Wanlapakorn, Nasamon, Diaz-Brito, Vicens, Tommelein, Eline, Esposito, Susanna
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.12.2021
• Subjects: 2019-nCoV Vaccine mRNA-1273 - adverse effects; 2019-nCoV Vaccine mRNA-1273 - immunology; Ad26COVS1 - adverse effects; Ad26COVS1 - immunology; Adoptive Transfer; Antibodies, Viral - immunology; BNT162 Vaccine - adverse effects; BNT162 Vaccine - immunology; COVID-19; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 Vaccines - adverse effects; COVID-19 Vaccines - immunology; Female; Humans; Immunology; Infectious Disease Transmission, Vertical - prevention & control; maternal immunization; maternal vaccination program; Maternal-Fetal Exchange - immunology; Milk, Human - immunology; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - prevention & control; Pregnancy Complications, Infectious - virology; pregnant women; SARS-CoV-2; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - immunology; Vaccination; Vaccine Efficacy - statistics & numerical data; COVID-19; SARS-CoV-2; pregnant women; maternal vaccination program; maternal immunization
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2021.808064

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy is associated with a higher risk for severe morbidity and mortality when compared with infection in non-pregnant women of childbearing age. An increasing number of countries recommend immunization against SARS-CoV-2 in pregnant women. Recent studies provide preliminary and supportive evidence on safety, immunogenicity and effectiveness of coronavirus disease 2019 (COVID-19) vaccines in pregnant women; however, important knowledge gaps remain which warrant further studies. This collaborative consensus paper provides a review of the current literature on COVID-19 vaccines in pregnant women, identifies knowledge gaps and outlines priorities for future research to optimize protection against SARS-CoV-2 in the pregnant women and their infants.