Exploring the Role of Contactins across Psychological, Psychiatric and Cardiometabolic Traits within UK Biobank

Individuals with severe mental illness have an increased risk of cardiometabolic diseases compared to the general population. Shared risk factors and medication effects explain part of this excess risk; however, there is growing evidence to suggest that shared biology (including genetic variation) i...

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Published inGenes Vol. 11; no. 11; p. 1326
Main Authors Morris, Julia, Leung, Soddy Sau Yu, Bailey, Mark E S, Cullen, Breda, Ferguson, Amy, Graham, Nicholas, Johnston, Keira J A, Lyall, Donald M, Lyall, Laura M, Ward, Joey, Smith, Daniel J, Strawbridge, Rona J
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 10.11.2020
MDPI
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Summary:Individuals with severe mental illness have an increased risk of cardiometabolic diseases compared to the general population. Shared risk factors and medication effects explain part of this excess risk; however, there is growing evidence to suggest that shared biology (including genetic variation) is likely to contribute to comorbidity between mental and physical illness. Contactins are a family of genes involved in development of the nervous system and implicated, though genome-wide association studies, in a wide range of psychological, psychiatric and cardiometabolic conditions. Contactins are plausible candidates for shared pathology between mental and physical health. We used data from UK Biobank to systematically assess how genetic variation in contactin genes was associated with a wide range of psychological, psychiatric and cardiometabolic conditions. We also investigated whether associations for cardiometabolic and psychological traits represented the same or distinct signals and how the genetic variation might influence the measured traits. We identified: A novel genetic association between variation in and current smoking; two independent signals in for BMI; and demonstrated that associations between and neuroticism were distinct from those between and blood pressure/HbA1c. There was no evidence that the contactin genes contributed to shared aetiology between physical and mental illness.
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ISSN:2073-4425
2073-4425
DOI:10.3390/genes11111326