The Dynamics of B Cell Aging in Health and Disease

Aging is considered to be an important risk factor for several inflammatory diseases. B cells play a major role in chronic inflammatory diseases by antibody secretion, antigen presentation and T cell regulation. Different B cell subsets have been implicated in infections and multiple autoimmune dise...

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Published inFrontiers in immunology Vol. 12; p. 733566
Main Authors de Mol, Jill, Kuiper, Johan, Tsiantoulas, Dimitrios, Foks, Amanda C
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 05.10.2021
Subjects
aging
Aging - immunology
Animals
Antibody Formation
atherosclerosis
autoimmune diseases
Autoimmune Diseases - immunology
B cells
B-Lymphocyte Subsets - immunology
B-Lymphocytes - immunology
Cellular Senescence
Humans
Immunology
immunosenescence
inflammaging
Inflammation - immunology
Lymphocyte Activation
atherosclerosis
autoimmune diseases
immunosenescence
inflammaging
B cells
aging
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Summary:Aging is considered to be an important risk factor for several inflammatory diseases. B cells play a major role in chronic inflammatory diseases by antibody secretion, antigen presentation and T cell regulation. Different B cell subsets have been implicated in infections and multiple autoimmune diseases. Since aging decreases B cell numbers, affects B cell subsets and impairs antibody responses, the aged B cell is expected to have major impacts on the development and progression of these diseases. In this review, we summarize the role of B cells in health and disease settings, such as atherosclerotic disease. Furthermore, we provide an overview of age-related changes in B cell development and function with respect to their impact in chronic inflammatory diseases.
Bibliography:ObjectType-Article-1
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Edited by: Guobing Chen, Jinan University, China
Reviewed by: Yi Hao, Huazhong University of Science and Technology, China; Arya Biragyn, National Institute on Aging (NIH), United States
This article was submitted to B Cell Biology, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.733566