Review of LINC00707: A Novel LncRNA and Promising Biomarker for Human Diseases

Long noncoding RNAs (lncRNAs) are a major type of noncoding RNA greater than 200 nucleotides in length involved in important regulatory processes. Abnormal expression of certain lncRNAs contributes to the pathogenesis of multiple diseases, including cancers. The lncRNA LINC00707 is located on chromo...

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Published inFrontiers in cell and developmental biology Vol. 10; p. 813963
Main Authors Yao, Qinfan, Li, Zheng, Chen, Dajin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 26.01.2022
Subjects
Cell and Developmental Biology
clinical characteristic
function
LINC00707
lncRNA
mechanism
LINC00707
lncRNA
mechanism
clinical characteristic
function
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Summary:Long noncoding RNAs (lncRNAs) are a major type of noncoding RNA greater than 200 nucleotides in length involved in important regulatory processes. Abnormal expression of certain lncRNAs contributes to the pathogenesis of multiple diseases, including cancers. The lncRNA LINC00707 is located on chromosome 10p14 and is abnormally expressed in numerous disease types, and particularly in several types of cancer. High LINC00707 levels mediate a series of biological functions, including cell proliferation, apoptosis, metastasis, invasion, cell cycle arrest, inflammation, and even osteogenic differentiation. In this review, we discuss the main functions and underlying mechanisms of LINC00707 in different diseases and describe promising applications of LINC00707 in clinical settings.
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Reviewed by: Jiping Yue, University of Chicago, United States
Edited by: Ritu Kulshreshtha, Indian Institute of Technology Delhi, India
Yuanwen Jiang, Stanford University, United States
This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.813963