Antinociceptive activity of the volatile oils of Hyptis pectinata L. Poit. (Lamiaceae) genotypes

• Published in: Phytomedicine (Stuttgart) Vol. 15; no. 5; pp. 334 - 339
• Main Authors: Arrigoni-Blank, M.F., Antoniolli, A.R., Caetano, L.C., Campos, D.A., Blank, A.F., Alves, P.B.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.05.2008; Urban & Fischer Verlag
• Subjects: Acetic-acid-induced abdominal constrictions; Acute toxicity; Analgesics - chemistry; Analgesics - pharmacology; Analgesics - therapeutic use; Animals; Bacterial infections; Care and treatment; Chemical properties; Control; Essences and essential oils; Female; Genotype; Health aspects; Hot-plate test; Hyptis - chemistry; Hyptis - classification; Hyptis - genetics; Hyptis pectinata; Lamiaceae; Male; Mice; Native medicinal plant; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; Oils, Volatile - therapeutic use; Pain - drug therapy; Phytotherapy; Brazil; Acetic-acid-induced abdominal constrictions; Native medicinal plant; Hyptis pectinata; Hot-plate test; Acute toxicity
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1016/j.phymed.2007.09.009

Hyptis pectinata L. Poit (Lamiaceae) is known popularly in Brazil as “sambacaita” or “canudinho” and is used in the treatment of inflammations, bacterial infections and ache. The antinociceptive activity of the volatile oils of six genotypes, at doses of 100, 200 and 400 mg/kg body wt., were investigated using abdominal writhe models induced by acetic acid and hot plate tests. The volatile oils of all the genotypes are composed mainly of sesquiterpenoids. All the genotypes showed antinociceptive effects in both models used; the SAM002 genotype showed the major inhibitory effect at dose of 100 mg/kg body wt. These results suggest that the volatile oil of H. pectinata has peripheral (writhe reduction) and central (time delay of thermal reaction) effects. These observations indicate that H. pectinata may be useful as an analgesic drug.