Acupuncture May Stimulate Anticancer Immunity via Activation of Natural Killer Cells

• Published in: Evidence-based complementary and alternative medicine Vol. 2011; no. 2011; pp. 1 - 14
• Main Authors: Johnston, Michael Francis, Ortiz Sánchez, Elizabeth, Vujanovic, Nikola L., Li, Wenhui
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2011; Hindawi Publishing Corporation; Hindawi Limited
• Subjects: Acupuncture; Cancer; Cancer therapies; Carcinogens; Chemotherapy; Cytokines; Cytotoxicity; Disease prevention; Hypotheses; Immune response; Immune system; Immunity (Disease); Immunology; Molecular chains; Narcotics; Natural killer cells; Nitric oxide; Pain; Patients; Receptor mechanisms; Review; Vomiting
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1093/ecam/nep236

This article presents the hypothesis that acupuncture enhances anticancer immune functions by stimulating natural killer (NK) cells. It provides background information on acupuncture, summarizes the current scientific understanding of the mechanisms through which NK cells act to eliminate cancer cells, and reviews evidence that acupuncture is associated with increases in NK cell quantity and function in both animals and humans. The key contribution of this article involves the use of cellular immunology and molecular biological theory to interpret and synthesize evidence from disparate animal and human studies in formulating the ‘acupuncture immuno-enhancement hypothesis’: clinicians may use acupuncture to promote the induction and secretion of NK-cell activating cytokines that engage specific NK cell receptors that endogenously enhance anticancer immune function.