Impact of isolated obesity on ICSI outcome

• Published in: Reproductive biomedicine online Vol. 17; no. 4; pp. 583 - 587
• Main Authors: Esinler, I, Bozdag, G, Yarali, H
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 2008
• Subjects: Adult; assisted reproduction treatment; Body Mass Index; Cryopreservation; Embryo Transfer; Female; Humans; Infertility - complications; Infertility - therapy; intracytoplasmic sperm injection; IVF; obesity; Obesity - complications; Obesity - pathology; Obstetrics and Gynecology; overweight; Pregnancy; Pregnancy Rate; Retrospective Studies; Sperm Injections, Intracytoplasmic; Treatment Outcome; IVF; assisted reproduction treatment; intracytoplasmic sperm injection; overweight; body mass index; obesity
• ISSN: 1472-6483; 1472-6491
• DOI: 10.1016/S1472-6483(10)60249-0

Abstract The aim of this study was to assess the impact of isolated obesity on the outcome of intracytoplasmic sperm injection (ICSI). A total of 775 patients undergoing 1113 ICSI cycles were categorized on the basis of body mass index (BMI): group 1 (BMI 18.5–24.9 kg/m2 ; normal weight; n = 627 cycles), group 2 (BMI 25.0–29.9 kg/m m2 ; overweight; n = 339 cycles) and group 3 (BMI ≥30 kg/m2 ; obese; n = 147 cycles). Sixty-three (10.0%) cycles in group 1, 53 (15.6%) cycles in group 2 and 26 cycles (17.7%) in group 3 were cancelled ( P < 0.05 for group 1 versus groups 2 and 3). Despite the significantly higher total gonadotrophin consumption in groups 2 and 3 compared with group 1, the mean serum oestradiol level on the day of human chorionic gonadotrophin administration was significantly higher in group 1 ( P < 0.05). The number of cumulus–oocyte complexes, metaphase II oocytes, and two-pronucleated oocytes were significantly lower in group 3 compared with group 1 ( P < 0.05). However, fertilization rate, the mean number of embryos transferred, the mean number of grade 1 embryos transferred, clinical pregnancy, implantation, multiple pregnancy and miscarriage rates were comparable among the three groups. The rate of cycles with cryopreservable embryos was significantly lower in groups 2 and 3 compared with group 1 ( P < 0.05).