Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms

Exposure to arsenic in drinking water is a worldwide health problem. This pollutant is associated with increased risk of developing chronic diseases, including metabolic diseases. Metabolic syndrome (MS) is a complex pathology that results from the interaction between environmental and genetic facto...

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Published inFrontiers in endocrinology (Lausanne) Vol. 13; p. 878280
Main Authors Pánico, Pablo, Velasco, Myrian, Salazar, Ana María, Picones, Arturo, Ortiz-Huidobro, Rosa Isela, Guerrero-Palomo, Gabriela, Salgado-Bernabé, Manuel Eduardo, Ostrosky-Wegman, Patricia, Hiriart, Marcia
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.05.2022
Subjects
arsenic
beta-cell
cardiovascular diseases
Endocrinology
insulin resistance
metabolic syndrome
obesity
metabolic syndrome
cardiovascular diseases
arsenic
beta-cell
insulin resistance
obesity
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Summary:Exposure to arsenic in drinking water is a worldwide health problem. This pollutant is associated with increased risk of developing chronic diseases, including metabolic diseases. Metabolic syndrome (MS) is a complex pathology that results from the interaction between environmental and genetic factors. This condition increases the risk of developing type 2 diabetes, cardiovascular diseases, and cancer. The MS includes at least three of the following signs, central obesity, impaired fasting glucose, insulin resistance, dyslipidemias, and hypertension. Here, we summarize the existing evidence of the multiple mechanisms triggered by arsenic to developing the cardinal signs of MS, showing that this pollutant could contribute to the multifactorial origin of this pathology.
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This article was submitted to Diabetes: Molecular Mechanisms, a section of the journal Frontiers in Endocrinology
Edited by: Francisco Westermeier, FH Joanneum, Austria
Reviewed by: Romina Bertinat, University of Concepcion, Chile; Robert Sargis, University of Illinois at Chicago, United States
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.878280