Fundamental interstrain differences in cortical activity between Wistar and Sprague–Dawley rats during global ischemia

• Published in: Neuroscience Vol. 228; pp. 371 - 381
• Main Authors: Fuzik, J, Gellért, L, Oláh, G, Herédi, J, Kocsis, K, Knapp, L, Nagy, D, Kincses, Z.T, Kis, Z, Farkas, T, Toldi, J
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 03.01.2013; Elsevier
• Subjects: Animals; Biological and medical sciences; Brain Ischemia - genetics; Brain Ischemia - physiopathology; burst suppression ratio; Cerebral Cortex - physiology; electrocorticogram; four-vessel occlusion; global ischemia; Medical sciences; Neurology; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Sprague–Dawley strain; Vascular diseases and vascular malformations of the nervous system; Wistar strain; BSR; PBS; electrocorticogram; CBF; EEG; burst suppression ratio; Wistar strain; phosphate-buffered saline; 4VO; CCAs; electroencephalogram; global ischemia; ECoG; cerebral blood flow; first burst; Sprague–Dawley strain; FB; four-vessel occlusion; common carotid arteries; Occlusion; Nervous system diseases; Rat; Sprague― Dawley strain; Rodentia; Electrophysiology; Cardiovascular disease; Strain specificity; Cerebral disorder; Vascular disease; Vertebrata; Mammalia; Animal; Central nervous system disease; Interindividual comparison; Brain ischemia; Cerebrovascular disease; Electrocorticography
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.10.042

Graphical abstract Highlights ► Wistar and Sprague–Dawley rats display interstrain differences in ischemic responses. ► Following 4VO, the FB and BSR values of the two strains differed considerably. ► The power spectrum of Sprague–Dawley rats was similar pre- and post-4VO. ► Evans Blue, Cresyl Violet and Fluoro Jade C stainings supplement ECoG data. ► Damage to the CA1 pyramids was severe in Wistar rats, but only partial in SD rats.