A characterization of white matter pathology following spinal cord compression injury in the rat

• Published in: Neuroscience Vol. 260; pp. 227 - 239
• Main Authors: Ward, R.E, Huang, W, Kostusiak, M, Pallier, P.N, Michael-Titus, A.T, Priestley, J.V
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 28.02.2014; Elsevier
• Subjects: Animals; axons; Biological and medical sciences; compression injury; demyelination; Female; Fundamental and applied biological sciences. Psychology; Nerve Fibers, Myelinated - ultrastructure; neurofilament; Neurofilament Proteins - metabolism; Neurology; Neurons - metabolism; Neurons - ultrastructure; Rats; Rats, Sprague-Dawley; Spinal Cord Compression - pathology; spinal cord injury; Thoracic Vertebrae; Vertebrates: nervous system and sense organs; white matter; immunoreactivity; propylene oxide; phosphate buffer; dorsolateral white matter; PFA; phosphate-buffered saline; β-APP; neurofilament-200; white matter; FITC; axons; NF-200; ventrolateral white matter; demyelination; MBP; compression injury; paraformaldehyde; fluorescein isothiocyanate; PBS; spinal cord injury; dorsal column; VLWM; CST; IR; myelin basic protein; VWM; PB; tetramethylrhodamine isothiocyanate; neurofilament; corticospinal tract; SCI; microtubule associated protein-2; β-amyloid precursor protein; MAP-2; TRITC; ventral white matter; DLWM; DC; PO; Spinal cord; Rat; Rodentia; Central nervous system; Axon; White matter; Characterization; Vertebrata; Neurofilament; Mammalia; Demyelination; Animal; Lesion
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.12.024

Highlights • The first characterization of axonal pathology in a rat static compression spinal injury. • Loss of axonal proteins at the lesion epicenter occurs within 1 day of injury. • At 6 weeks, myelination by oligodendrocytes and Schwann cells follows early myelin loss. • The injury spreads both rostral and caudal to the epicenter.