The Advantages of Connectivity Map Applied in Traditional Chinese Medicine

Amid the establishment and optimization of Connectivity Map (CMAP), the functional relationships among drugs, genes, and diseases are further explored. This biological database has been widely used to identify drugs with common mechanisms, repurpose existing drugs, discover the molecular mechanisms...

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Published inFrontiers in pharmacology Vol. 12; p. 474267
Main Authors Jiang, Huimin, Hu, Cheng, Chen, Meijuan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 11.03.2021
Subjects
Chinese herbal compound
connectivity map
Pharmacology
synergetic mechanism
TCM repurposing
traditional Chinese medicine
synergetic mechanism
traditional Chinese medicine
connectivity map
TCM repurposing
Chinese herbal compound
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Summary:Amid the establishment and optimization of Connectivity Map (CMAP), the functional relationships among drugs, genes, and diseases are further explored. This biological database has been widely used to identify drugs with common mechanisms, repurpose existing drugs, discover the molecular mechanisms of unknown drugs, and find potential drugs for some diseases. Research on traditional Chinese medicine (TCM) has entered a new era in the wake of the development of bioinformatics and other subjects including network pharmacology, proteomics, metabolomics, herbgenomics, and so on. TCM gradually conforms to modern science, but there is still a torrent of limitations. In recent years, CMAP has shown its distinct advantages in the study of the components of TCM and the synergetic mechanism of TCM formulas; hence, the combination of them is inevitable.
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Yan Lin, Guizhou Medical University, China
This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology
Reviewed by: Hong-Yu Zhang, Huazhong Agricultural University, China
Edited by: Lie-Fen Shyur, Agricultural Biotechnology Research Center, Taiwan
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.474267