Temporal and spatial dynamics of rabies viruses in China and Southeast Asia

Phylogenetic studies have revealed a profound understanding about the biodiversity of rabies viruses in China, but little is known about their evolutionary dynamics in the country. In the present study, the complete G gene sequences of 33 rabies virus isolates (RABVs) isolated from distinct Chinese...

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Published inVirus research Vol. 150; no. 1; pp. 111 - 118
Main Authors Gong, Wenjie, Jiang, Yu, Za, Yunfeng, Zeng, Zheng, Shao, Mingfu, Fan, Jinhong, Sun, Yanwei, Xiong, Zhonglian, Yu, Xinglong, Tu, Changchun
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2010
Subjects
Animals
Antigens, Viral - genetics
Asia, Southeastern - epidemiology
Cattle
China
China - epidemiology
Cluster Analysis
Dogs
Evolution, Molecular
Evolutionary dynamics
Geography
Glycoproteins - genetics
Humans
Molecular Sequence Data
Phylogeny
Rabies - epidemiology
Rabies - veterinary
Rabies - virology
Rabies virus
Rabies virus - classification
Rabies virus - genetics
Rabies virus - isolation & purification
RNA, Viral - genetics
Sequence Analysis, DNA
Sequence Homology
Swine
Time Factors
Viral Envelope Proteins - genetics
Asia, Southeastern
China
Rabies virus
Evolutionary dynamics
China
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Summary:Phylogenetic studies have revealed a profound understanding about the biodiversity of rabies viruses in China, but little is known about their evolutionary dynamics in the country. In the present study, the complete G gene sequences of 33 rabies virus isolates (RABVs) isolated from distinct Chinese provinces were determined and phylogenetic analysis was conducted using these G sequences and 93 others retrieved from GenBank representing China and Southeast Asia. Further evolutionary history of RABV was estimated using a Bayesian Markov chain Monte Carlo method to understand the temporal and spatial dynamics of this virus. Results showed that rabies viruses in China and Southeast Asia share a common ancestor and form 2 clades with each being further divided into 3 lineages. The time of the most recent common ancestor of current RABV strains was estimated to be year 1654 (1514–1812) and the viruses circulating in Southeast Asia likely derived from China.
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ISSN:0168-1702
1872-7492
DOI:10.1016/j.virusres.2010.02.019