Sea cucumber ( Acaudina leucoprocta ) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans

• Published in: Frontiers in nutrition (Lausanne) Vol. 9; p. 1065145
• Main Authors: Wu, Yue, Yang, Jingjuan, Xu, Chengmei, Li, Qiuqi, Ma, Yage, Zhao, Shenglan, Zhuang, Jiachen, Shen, Fei, Wang, Qianqian, Feng, Fengqin, Zhang, Xi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 22.11.2022
• Subjects: anti-aging; antioxidant; Caenorhabditis elegans; insulin/IGF-1 signaling; Nutrition; sea cucumber peptide; Caenorhabditis elegans; anti-aging; antioxidant; sea cucumber peptide; insulin/IGF-1 signaling
• ISSN: 2296-861X; 2296-861X
• DOI: 10.3389/fnut.2022.1065145

The sea cucumber peptides (SCPs) from were derived from the patented bio-enzyme digestion technology and the molecular weight of obtained SCPs was < 10 kDa. In this study, we investigated the possible anti-aging effects of SCPs on the model of and the underlying mechanisms. SCPs extend the average lifespan of nematodes by 31.46%. SCPs enhance the anti-stress capacity of by improving heat resistance and mobility, Also, the accumulated potential oxidative stress inducers like lipofuscin and reactive oxygen species (ROS) were reduced to 40.84 and 71.43%. In addition, SCPs can increase the antioxidant capacity in nematodes by enhancing the activity of SOD and CAT and reducing MDA accumulation in nematodes to 32.44%. Mechanistically, SCPs could mediate DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 axis to improve antioxidant capacity and extend lifespan in nematodes. Taken together, these findings provide a direction for the anti-aging effects of sea cucumber peptides and new insights into the further purifications of SCPs and future research on aging.