Thinking Outside the Frame: Impacting Genomes Capacity by Programmed Ribosomal Frameshifting

Translation facilitates the transfer of the genetic information stored in the genome via messenger RNAs to a functional protein and is therefore one of the most fundamental cellular processes. Programmed ribosomal frameshifting is a ubiquitous alternative translation event that is extensively used b...

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Published inFrontiers in molecular biosciences Vol. 9; p. 842261
Main Authors Riegger, Ricarda J, Caliskan, Neva
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 14.02.2022
Subjects
frameshifting
Molecular Biosciences
ribosome
RNA
translation
translational regulation
viruses
translation
frameshifting
ribosome
viruses
translational regulation
RNA
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Summary:Translation facilitates the transfer of the genetic information stored in the genome via messenger RNAs to a functional protein and is therefore one of the most fundamental cellular processes. Programmed ribosomal frameshifting is a ubiquitous alternative translation event that is extensively used by viruses to regulate gene expression from overlapping open reading frames in a controlled manner. Recent technical advances in the translation field enabled the identification of precise mechanisms as to how and when ribosomes change the reading frame on mRNAs containing -acting signals. Several studies began also to illustrate that -acting RNA modulators can adjust the timing and efficiency of frameshifting illuminating that frameshifting can be a dynamically regulated process in cells. Here, we intend to summarize these new findings and emphasize how it fits in our current understanding of PRF mechanisms as previously described.
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John Atkins, University College Cork, Ireland
Edited by: Norbert Polacek, University of Bern, Switzerland
Reviewed by: Jonathan Dinman, University of Maryland, College Park, United States
This article was submitted to RNA Networks and Biology, a section of the journal Frontiers in Molecular Biosciences
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2022.842261