Predictors of Comorbid Conditions in Women Who Carry an FMR1 Premutation

Women who carry an premutation (PM) can experience two well-established PM-associated disorders: fragile X-associated primary ovarian insufficiency (FXPOI, affects ~20-30% carriers) and fragile X-associated tremor-ataxia syndrome (FXTAS, affects ~6-15% carriers); however, emerging evidence indicates...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in psychiatry Vol. 12; p. 715922
Main Authors Allen, Emily Graves, Charen, Krista, Hipp, Heather S, Shubeck, Lisa, Amin, Ashima, He, Weiya, Hunter, Jessica Ezzell, Shelly, Katharine E, Sherman, Stephanie L
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.10.2021
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Women who carry an premutation (PM) can experience two well-established PM-associated disorders: fragile X-associated primary ovarian insufficiency (FXPOI, affects ~20-30% carriers) and fragile X-associated tremor-ataxia syndrome (FXTAS, affects ~6-15% carriers); however, emerging evidence indicates that some of these women experience complex health profiles beyond FXPOI and FXTAS. In an effort to better understand predictors for these comorbid conditions, we collected self-reported medical histories on 413 women who carry an PM. There were 22 health conditions reported by at least 9% of women. In an exploratory analysis, 12 variables were tested in logistic regression models for each comorbid condition, including demographic variables, environmental variables, PM-associated factors, and endorsement of depression and/or anxiety. More than half of the comorbid conditions studied were associated with women who self-reported having anxiety. Age, smoking, body mass index (BMI), and depression were also significant predictor variables for specific comorbid conditions. Age, smoking, and BMI were significantly associated with a subset of the comorbid conditions analyzed. Importantly, depression or anxiety were also significantly associated with many of the comorbid health conditions. This work highlights some of the modifiable factors associated with complex health profiles among women with an PM.
Bibliography:This article was submitted to Behavioral and Psychiatric Genetics, a section of the journal Frontiers in Psychiatry
Edited by: David Hessl, University of California, Davis, United States
Reviewed by: Susan Elizabeth Luczak, University of Southern California, United States; Laia Rodriguez-Revenga, Hospital Clínic de Barcelona, Spain; Shai E. Elizur, Sheba Medical Center, Israel
ISSN:1664-0640
1664-0640
DOI:10.3389/fpsyt.2021.715922