Comparison of Three Motor Subtype Classifications in de novo Parkinson's Disease Patients
The aims of this study were to compare the characteristics of three motor subtype classifications in patients with Parkinson's disease (PD) and to find the most suitable motor subtype classification for identifying non-motor symptoms (NMSs). According to previous studies, a total of 256 patient...
Saved in:
Published in | Frontiers in neurology Vol. 11; p. 601225 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
23.12.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The aims of this study were to compare the characteristics of three motor subtype classifications in patients with
Parkinson's disease (PD) and to find the most suitable motor subtype classification for identifying non-motor symptoms (NMSs).
According to previous studies, a total of 256 patients with
PD were classified using the tremor-dominant/mixed/akinetic-rigid (TD/mixed/AR), TD/indeterminate/postural instability and gait disturbance (PIGD), and predominantly TD/predominantly PIGD (p-TD/p-PIGD) classification systems.
Among the TD/mixed/AR subgroups, the patients with the AR subtype obtained more severe motor scores than the patients with the TD subtype. Among the TD/indeterminate/PIGD subgroups and between the p-TD and p-PIGD subgroups, the patients with the PIGD/p-PIGD subtype obtained more severe scores related to activities of daily living (ADL), motor and non-motor symptoms, including depression, anxiety, and sleep impairment, than the patients with the TD/p-TD subtype. Furthermore, symptoms in the cardiovascular, gastrointestinal, and miscellaneous domains of the Non-motor Questionnaire (NMSQuest) were more prevalent in the patients with the PIGD/p-PIGD subtypes than the patients with the TD/p-TD subtypes.
The PIGD/p-PIGD subtypes had more severe ADL, motor and non-motor symptoms than the TD/p-TD subtypes. We disclosed for the first time that the TD/indeterminate/PIGD classification seems to be the most suitable classification among the three motor subtype classifications for identifying NMSs in PD. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Movement Disorders, a section of the journal Frontiers in Neurology Weiguo Liu orcid.org/0000-0001-5916-9837 ORCID: Jingru Ren orcid.org/0000-0002-9186-6621 Reviewed by: Matteo Bologna, Sapienza University of Rome, Italy; Marcello Moccia, University of Naples Federico II, Italy Edited by: Maria Teresa Pellecchia, University of Salerno, Italy |
ISSN: | 1664-2295 1664-2295 |
DOI: | 10.3389/fneur.2020.601225 |