Type I Interferons in Host Defense

Type I interferons (IFNs) are a family of cytokines specialized to coordinate immunity to viruses and other intracellular infections. In the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of type I IFNs have been identified and characterize...

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Published inImmunity (Cambridge, Mass.) Vol. 25; no. 3; pp. 373 - 381
Main Authors Stetson, Daniel B., Medzhitov, Ruslan
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2006
Elsevier Limited
Subjects
Animals
Bacteria
Deoxyribonucleic acid
DNA
Genomes
Humans
Immune system
Immunity, Innate
Infections
Interferon Type I - biosynthesis
Interferon Type I - physiology
Medical research
Signal Transduction - immunology
Vertebrates
Viral infections
Virus Diseases - immunology
Virus Diseases - metabolism
Viruses
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Summary:Type I interferons (IFNs) are a family of cytokines specialized to coordinate immunity to viruses and other intracellular infections. In the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of type I IFNs have been identified and characterized. An integrated picture has emerged in which type I IFNs have essential functions in several seemingly disparate processes: they restrict viral spread by engaging machinery that ultimately cripples and kills infected cells, yet they are also positively linked to the activation and expansion of lymphocytes that are important for control of intracellular infections. These advances highlight the context-specific actions of type I IFNs and clarify the multiple points at which they are integrated into both innate and adaptive immunity.
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2006.08.007