Circulating and dietary advanced glycation end products and obesity in an adult population: A paradox of their detrimental effects in obesity

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 966590
• Main Authors: Turki Jalil, Abduladheem, Alameri, Ameer A, Iqbal Doewes, Rumi, El-Sehrawy, Amr A, Ahmad, Irfan, Ramaiah, Pushpamala, Kadhim, Mustafa M, Kzar, Hamzah H, Sivaraman, R, Romero-Parra, Rosario Mireya, Ansari, Mohammad Javed, Fakri Mustafa, Yasser
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.12.2022
• Subjects: Adult; AGEs; BMI - body mass index; Body Mass Index; cardiovascular disease; Dietary Advanced Glycation End Products; Endocrinology; Glycation End Products, Advanced; Humans; obesity; Obesity - epidemiology; sRAGE level; cardiovascular disease; AGEs; sRAGE level; BMI - body mass index; obesity
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2022.966590

The detrimental role of advanced glycation end products (AGEs) against cardio-metabolic health has been revealed in several previous reports. However, the results of studies regarding the association between AGEs and obesity measurements are inconsistent. In the current meta-analysis, we aimed to quantitatively summarize the results of studies that evaluated the association between circulating and dietary AGEs with obesity measurements among the adult population. A systematic search from PubMed, Embase, and Scopus electronic databases until 30 October 2022 retrieved a total of 21,429 observational studies. After duplicate removal, title/abstract screening, and full-text reading by two independent researchers, a final number of 18 manuscripts remained to be included in the meta-analysis. Those in the highest category of circulating AGEs had ~1.5 kg/m reduced BMI compared with those in the lowest AGEs category [weighted mean difference (WMD): -1.485; CI: -2.459, -0.511; = 0.003], while a nonsignificant increase in BMI was observed in the highest versus lowest category of dietary AGEs (WMD: 0.864, CI: -0.365, 2.094; = 0.186). Also, lower amounts of circulating AGEs in individuals with obesity versus individuals without obesity were observed (WMD: -57.220, CI: -84.290, -30.149; < 0.001). AGE type can be considered as a possible source of heterogeneity. In the current meta-analysis, we observed an inverse association between circulating AGEs and body mass index among adults. Due to low study numbers, further studies are warranted to better elucidate these results.